Direct observation of minimum-sized amyloid fibrils using solution NMR spectroscopy
نویسندگان
چکیده
منابع مشابه
Probing solvent accessibility of amyloid fibrils by solution NMR spectroscopy.
Amyloid is the result of an anomalous protein and peptide aggregation, leading to the formation of insoluble fibril deposits. At present, 18 human diseases have been associated with amyloid deposits-e.g., Alzheimer's disease and Prion-transmissible Spongiform Encephalopathies. The molecular structure of amyloid is to a large extent unknown, because of lack of high-resolution structural informat...
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ژورنال
عنوان ژورنال: Protein Science
سال: 2010
ISSN: 0961-8368
DOI: 10.1002/pro.515